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This book covers new techniques in protein NMR, from basic principles to state-of-the-art research. It covers a spectrum of topics ranging from a “toolbox” for how sequence-specific resonance assignments can be obtained using a suite of 2D and 3D NMR experiments and tips on how overlap problems can be overcome. Further topics include the novel applications of Overhauser dynamic nuclear polarization methods (DNP), assessing protein structure, and aspects of solid-state NMR of macroscopically aligned membrane proteins. This book is an ideal resource for students and researchers in the fields of biochemistry, chemistry, and pharmacology and NMR physics. Comprehensive and intuitively structured, this book examines protein NMR and new novel applications that include the latest technological advances. This book also has the features of: • A selection of various applications and cutting-edge advances, such as novel applications of Overhauser dynamic nuclear polarization methods (DNP) and a suite of 2D and 3D NMR experiments and tips on how overlap problems can be overcome • A pedagogical approach to the methodology • Engaging the reader and student with a clear, yet critical presentation of the applications.

Molecular biology --- moleculaire biologie

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This complete, concise guide enables graduate students in speech-language pathology to apply their knowledge of the anatomy and physiology of voice and speech production to the study of normal deglutition and dysphagia. The text examines the oral, pharyngeal, and esophageal components of the swallow mechanism, identifying both normal structure and morphology and structural and physiologic abnormalities. The Second Edition has been carefully updated to reflect current evidence and evolving theoretical frameworks for a wide range of diagnostic and treatment approaches, as well as the analytical process needed to effectively evaluate current and future research results. The text also features new material on neurological control, motor control, and learning, in addition to information on new technology and treatment techniques, such as electrical stimulation, free water protocols, Shaker exercises, and use of the National Dysphagia Diet. New and revised images clearly and consistently illustrate critical concepts of anatomy and physiology., The authors conversational writing style makes even complex material more engaging and easier to master and apply. This comprehensive, yet highly approachable text equips students to apply a systematic line of inquiry and evidence-based practice to diagnose and manage dysphagia accurately and efficiently.

Anatomie --- Fysiologie --- Dysfagie --- Biologie

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Mutualism (Biology) --- Evolution (Biology) --- Mutualisme (biologie) --- Évolution (biologie)

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Cells are by nature compelled to live in groups. They develop dependence over signaling cues received from their microenvironment, in particular from other cells, whether of their own “kind” or of a different type. Therefore, communicating with these cells is a critical aspect of their behavior and fate, as they live and die normally or as they undergo disease-related pathological changes, with dramatic repercussions. In this book, we have asked expert researchers in the field of Intercellular Communication in Cancer to provide chapters on different aspects of interaction between neighboring cells, in the context of cancer diseases. We have specifically focused our efforts on membrane-to-membrane contact-based rather than growth factors-mediated modes of intercellular communications. The contributing authors provide an extensive overview of their respective area of specialization, with an in-depth discussion of the molecular mechanisms of cell-cell interactions, the impact on tumor progression and response to therapies, as well as the cancer diagnostic value of this scientific information. This book aims to introduce essential aspects of the normal and pathological cellular fate and homeostasis to both scientists and clinicians, and also to provide established researchers with an update on the novelties and future directions this expanding field is witnessing.

Biology --- Oncology. Neoplasms --- biologie --- oncologie

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Extinctions massives --- Extinction (Biologie) --- Catastrophes écologiques --- Espèces (biologie) --- Extinction --- Extinction. --- Extinction (biologie)